They could easily be brother and sister
Skeletor is a fictional supervillain and the main antagonist of the Masters of the Universe franchise created by Mattel, serving as the archenemy of his nephew He-Man. He is typically depicted as a blue-skinned humanoid who wears a purple hood over his bare-bone skull.
Nancy Patricia Pelosi is an American politician serving as Speaker of the United States House of Representatives since 2019, and previously from 2007 to 2011. She is typically depicted as a thick-skinned humanoid who wears a crappy haircut over her hideous skull.